Hydroxychloroquine 400 mg known as HCQS 400 mg Tablet
Hydroxychloroquine 400 mg Tablet is utilized in the treatment of immune system conditions, for example, rheumatoid joint inflammation and fundamental lupus erythematosus. It dials back the movement of the sickness and gives alleviation from agony, enlarging, and redness.
HCQS 400 Tablet ought to be taken with food. This will keep you from getting a surprise stomach upset. You should take it routinely and simultaneously every day to get the most extreme advantage from it. Continue to accept it as suggested by your primary care physician and complete the portion regardless of whether you feel much improved.
The normal symptoms of this medication incorporate obscured vision and expanded affectability to light. It might even change the shade of your eyes. Talk with your primary care physician if any of these incidental effects don’t disappear with time or deteriorate. Your PCP might assist with approaches to lessen or forestall these side effects.
To ensure the medication is alright for you, prior to taking this medication, let your PCP know whether you have any issues with your heart, kidneys, or liver. Likewise, educate your PCP concerning the wide range of various prescriptions you are taking. Your primary care physician might prescribe customary eye tests to genuinely take a look at your vision while on this drug. Pregnant and breastfeeding moms ought to talk with their PCPs prior to taking the medication.
Uses of Hydroxychloroquine Pills
Rheumatoid Arthritis
Treatment of systemic lupus erythematosus (SLE).
Now its also uses to treatment of Covid-19 and it works really.
Common side effects for hydroxychloroquine 400 mg.
Most incidental effects don’t need any clinical consideration and vanish as your body changes with the medication. Counsel your primary care physician on the off chance that they persevere or then again in case you’re stressed over them.
Blurred Vision.
Increased Sensitivity to light.HOW TO USE HCQS TABLET.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. HCQS 400 Tablet is to be taken with food.
HOW HCQS TABLET WORKS.
HCQS 400 Tablet is a Disease Modifying Anti-Rheumatoid Drug (DMARD). It works by suppressing the overactivity of the immune system that causes inflammation (swelling) and pain in the joints. This slows the progression of the underlying disease.
Hydroxychloroquine 400mg, sold under the brand name HCQS-400 among others, is a medication used to prevent and treat malaria in areas where malaria remains sensitive to chloroquine. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth, often in the form of hydroxychloroquine sulfate. [2] Hydroxychloroquine is being studied to prevent and treat coronavirus disease 2019 (COVID‑19), but all clinical trials conducted during 2020 found it is ineffective and may cause dangerous side effects.
Common side effects may include vomiting, headache, changes in vision, and muscle weakness. [2] Severe side effects may include allergic reactions, vision problems, and heart problems.
[2] [7] Although all risk can not be excluded, it remains a treatment for rheumatic disease during pregnancy. [8] Hydroxychloroquine is in the antimalarial and 4-aminoquinoline families of medication. [2]
Hydroxychloroquine was approved for medical use in the United States in 1955. [2] It is on the World Health Organization’s List of Essential Medicines. [9] In 2017, it was the 128th most commonly prescribed medication in the United States, with more than five million prescriptions. [10]
[11] The speculative use of hydroxychloroquine for COVID‑19 threatens its availability for people with established indications. [4] Medical uses.
Hydroxychloroquine treats rheumatic disorders such as systemic lupus erythematosus, rheumatoid arthritis, and porphyria cutanea tarda, and certain infections such as Q fever and certain types of malaria. [2] It is considered the first-line treatment for systemic lupus erythematosus. [12] Certain types of malaria, resistant strains, and complicated cases require different or additional medication. [2]
It is widely used to treat primary Sjögren syndrome but does not appear to be effective. [13] Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. It may have both an anti-spirochete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. [14] Contraindications.
The drug label advises that hydroxychloroquine should not be prescribed to individuals with known hypersensitivity to 4-aminoquinoline compounds. [15] There are several other contraindications, [16] [17] and caution is required if the person considered for treatment has certain heart conditions, diabetes, or psoriasis.
Adverse effects.
The most common adverse effects are nausea, stomach cramps, and diarrhea. Other common adverse effects include itching and headache. [4] The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. [2] Serious reported neuropsychiatric adverse effects of hydroxychloroquine use include agitation, mania, difficulty sleeping, hallucinations, psychosis, catatonia, paranoia, depression, and suicidal thoughts. [4] In rare situations, hydroxychloroquine has been implicated in cases of serious skin reactions such as Stevens– Johnson syndrome, toxic epidermal necrolysis, and Drug reaction with eosinophilia and systemic symptoms. [4] Reported blood abnormalities with its use include lymphopenia, eosinophilia, and atypical lymphocytosis. [4]
For short-term treatment of acute malaria, adverse effects can include abdominal cramps, diarrhea, heart problems, reduced appetite, headache, nausea, and vomiting. [2] Other adverse effects noted with short-term use of Hydroxychloroquine include low blood sugar and QT interval prolongation. [3] Idiosyncratic hypersensitivity reactions have occurred. [4]
For prolonged treatment of lupus or rheumatoid arthritis, adverse effects include the acute symptoms, plus altered eye pigmentation, acne, anemia, bleaching of hair, blisters in the mouth and eyes, blood disorders, cardiomyopathy, [3] convulsions, vision difficulties, diminished reflexes, emotional changes, the excessive coloring of the skin, hearing loss, hives, itching, liver problems or liver failure, loss of hair, muscle paralysis, weakness or atrophy, nightmares, psoriasis, reading difficulties, tinnitus, skin inflammation, and scaling, skin rash, vertigo, weight loss, and occasionally urinary incontinence. [2] Hydroxychloroquine can worsen existing cases of both psoriasis and porphyria. [2]
Children may be especially vulnerable to developing adverse effects from hydroxychloroquine. [2] Eyes.
Main article: Chloroquine retinopathy.
One of the most serious side effects is retinopathy (generally with chronic use). [2] [18] People taking 400 mg of hydroxychloroquine or less per day generally have a negligible risk of macular toxicity, whereas the risk begins to increase when a person takes the medication over five years or has a cumulative dose of more than 1000 grams. The daily safe maximum dose for eye toxicity can be computed from a person’s height and weight. [19] Macular toxicity is related to the total cumulative dose rather than the daily dose. Regular eye screening, even in the absence of visual symptoms, is recommended to begin when either of these risk factors occurs. [20]
Toxicity from hydroxychloroquine may be seen in two distinct areas of the eye: the cornea and the macula. The cornea may become affected (relatively commonly) by an innocuous cornea verticillata or vortex keratopathy and is characterized by whorl-like corneal epithelial deposits. These changes bear no relationship to dosage and are usually reversible on cessation of hydroxychloroquine.
The macular changes are potentially serious. Advanced retinopathy is characterized by a reduction of visual acuity and a “bull’s eye” macular lesion which is absent in early involvement.
Overdose.
Overdoses of hydroxychloroquine are extremely rare but extremely toxic. [4] Eight people are known to have overdosed since the drug’s introduction in the mid-1950s, of which three have died. [21] [22] Chloroquine has a risk of death in overdose in adults of about 20%, while hydroxychloroquine is estimated to be two or threefold less toxic. [23]
Serious signs and symptoms of overdose generally occur within an hour of ingestion. [23] These may include sleepiness, vision changes, seizures, coma, stopping of breathing, and heart problems such as ventricular fibrillation and low blood pressure. [4] [23]
[24] Loss of vision may be permanent. [25] Low blood potassium, to levels of 1 to 2 mmol/L, may also occur. [23] [26] Cardiovascular abnormalities such as QRS complex widening and QT interval prolongation may also occur. [4]
Treatment recommendations include early mechanical ventilation, heart monitoring, and activated charcoal. [23] Supportive treatment with intravenous fluids and vasopressors may be required with epinephrine being the vasopressor of choice. [23] Stomach pumping may also be used. [21] Sodium bicarbonate and hypertonic saline may be used in cases of severe QRS complex widening. [4] Seizures may be treated with benzodiazepines. [23] Intravenous potassium chloride may be required, however this may result in high blood potassium later in the course of the disease. [23] Dialysis does not appear to be useful. [23] Detection.
Hydroxychloroquine may be quantified in plasma or serum to confirm a diagnosis of poisoning in hospitalized victims or in whole blood to assist in a forensic investigation of a case of sudden or unexpected death. Plasma or serum concentrations are usually in a range of 0.1-1.6 mg/L during therapy and 6– 20 mg/L in cases of clinical intoxication, while blood levels of 20– 100 mg/L have been observed in deaths due to acute overdosage. [27] Interactions.
The drug transfers into breast milk. [1] There is no evidence that its use during pregnancy is harmful to the developing fetus and its use is not contraindicated in pregnancy. [4]
The concurrent use of hydroxychloroquine and the antibiotic azithromycin appears to increase the risk for certain serious side effects with short-term use, such as an increased risk of chest pain, congestive heart failure, and mortality from cardiovascular causes.
[3] Care should be taken if combined with medication altering liver function as well as aurothioglucose (Solganal), cimetidine (Tagamet) or digoxin (Lanoxin).
Hydroxychloroquinecan increase plasma concentrations of penicillamine which may contribute to the development of severe side effects. It enhances the hypoglycemic effects of insulin and oral hypoglycemic agents. Dose altering is recommended to prevent profound hypoglycemia. Antacids may decrease the absorption of hydroxychloroquine. Both neostigmine and pyridostigmine antagonize the action of hydroxychloroquine. [28]
While there may be a link between hydroxychloroquine and hemolytic anemia in those with glucose-6-phosphate dehydrogenase deficiency, this risk may be low in those of African descent. [29]
Specifically, the US Food and Drug Administration’s (FDA) drug label for hydroxychloroquine lists the following drug interactions: [15]
Digoxin (wherein it may result in increased serum digoxin levels).
Insulin or anti-diabetic medication (wherein it may enhance the effects of a hypoglycemic treatment).
Drugs that prolong QT interval and other arrhythmogenic drugs (as Hydroxychloroquine prolongs the QT interval and may increase the risk of inducing serious abnormal heart rhythms (ventricular arrhythmias) if used concurrently) [7] Mefloquine and other drugs known to lower the seizure threshold (co-administration with other antimalarials known to lower the convulsion threshold may increase risk of convulsions).
Antiepileptics (concurrent use may impair the antiepileptic activity).
Methotrexate (combined use is unstudied and may increase the frequency of side effects).
Cyclosporin (wherein an increased plasma cyclosporin level was reported when used together).
Pharmacology
Pharmacokinetics.
Hydroxychloroquine has similar pharmacokinetics to chloroquine, with rapid gastrointestinal absorption, large distribution volume, [30] and elimination by the kidneys. Cytochrome P450 enzymes (CYP2D6, 2C8, 3A4 and 3A5) metabolize hydroxychloroquine to N-desethylhydroxychloroquine. [31] Both agents also inhibit CYP2D6 activity and may interact with other medications that depend on this enzyme. [4] Pharmacodynamics.
Antimalarials are lipophilic weak bases and easily pass plasma membranes. The free base form accumulates in lysosomes (acidic cytoplasmic vesicles) and is then protonated,
[32] resulting in concentrations within lysosomes up to 1000 times higher than in culture media. This increases the pH of the lysosome from four to six. [33] Alteration in pH causes inhibition of lysosomal acidic proteases causing a diminished proteolysis effect. [34] Higher pH within lysosomes causes decreased intracellular processing,
glycosylation, and secretion of proteins with many immunologic and nonimmunologic consequences. [35] These effects are believed to be the cause of a decreased immune cell functioning such as chemotaxis, phagocytosis and superoxide production by neutrophils. [36] Hydroxychloroquine is a weak diprotic base that can pass through the lipid cell membrane and preferentially concentrate in acidic cytoplasmic vesicles.
The higher pH of these vesicles in macrophages or other antigen-presenting cells limits the association of autoantigenic (any) peptides with class II MHC molecules in the compartment for peptide loading and/or the subsequent processing and transport of the peptide-MHC complex to the cell membrane. [37] Mechanism of action.
Hydroxychloroquine increases [38] lysosomal pH in antigen-presenting cells. [3] In inflammatory conditions, it blocks toll-like receptors on plasmacytoid dendritic cells (PDCs). [39] Toll-like receptor 9 (TLR 9), which recognizes DNA-containing immune complexes, leads to the production of interferon and causes the dendritic cells to mature and present antigen to T cells. Hydroxychloroquine, by decreasing TLR signaling, reduces the activation of dendritic cells and the inflammatory process. [medical citation needed]
In 2003, a novel mechanism was described wherein hydroxychloroquine inhibits stimulation of the toll-like receptor (TLR) 9 family receptors. TLRs are cellular receptors for microbial products that induce inflammatory responses through activation of the innate immune system. [40]
As with other quinoline antimalarial drugs, the antimalarial mechanism of action of quinine has not been fully resolved. The most accepted model is based on hydrochloroquinine and involves the inhibition of hemozoin biocrystallization, which facilitates the aggregation of cytotoxic heme. Free cytotoxic heme accumulates in the parasites, causing death. [41]
Hydroxychloroquine increases the risk of low blood sugar through several mechanisms. These include decreased clearance of the hormone insulin from the blood, increased insulin sensitivity, and increased release of insulin from the pancreas.
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